Identification and analysis of DNA repair mechanisms that contribute Literature review

Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues - Literature review Example Consequently, DNA is damaged frequently, and is repaired through pathways of repair and proofreading functions by DNA polymerase. Multiple mechanisms of repair within the cell act to balance these levels of mutation. However, the large number of mutations that occur means that every so often, the repair process misses these mutations and they become part of the DNA. This process can be the first step in carcinogenesis . There are currently 346 different genes that have been associated with the development of cancer, although this number continues to grow. In some cases these genes are mutated in cancer cells and not in normal cells. In other cases, genes may show substantial levels of deregulation. Both of these processes have the potential to significantly decrease the effectiveness of certain genes, leading to altered pathways within the cancer cell and the body itself . This suggests that mutations are a crucial part of the formation of cancer. Indeed, human cancer appears to have thousands of different mutations by the time that it is first detected. Furthermore, information that cancer can be inherited from one generation to the next suggests that some of these mutations can be passed along in genes . Cancer is characterised by high levels of clonal expansion of somatic cells. These cells are not subject to the normal growth regulation components of the cell cycle. Thus, they are able to proliferate beyond the normal constraints of tissue. Likewise, the controls over apoptosis are also circumvented . Most tumours that develop in the human body are substantially heterogeneous. This suggests that multiple mutations occur within human cancers driving the creation of tumours and the change in function between normal cells and cancerous cells . Thus, cancer can be considered to be a disease, or collection of diseases, that occurs due to genetic abnormalities accumulating within cells . In each generation of cancer cells, significant mutation occurs within diffe rent cells, and those that develop mutations that facilitate cancer growth are selected for, resulting in an increase in the prevalence of these cells. Mutations may be subtle, such as changes in the sequence of nucleotides, or more substantial, involving changes in the chromosomes themselves . One significant factor in cancer treatment resistance is that therapeutic killing cancer cells, while causing cancer to go into remission, can also act to select for resistance to treatment. This can result in a progression of tumour growth, with cells that cannot be targeted by the same treatment . Another form of resistance that can occur is based on the cells location in the division cycle. Cancer therapy tends to be most effective on cells that are rapidly replicating. Furthermore, resistance to treatment can often be stronger in some stages of the cell cycle than others . Cancer cells contain a wide range of mutations, and these mutations may act to drive the formation and progression of tu

How does Thomas Hardy create and maintain Essay Example for Free

How does Thomas Hardy create and maintain Essay How does Thomas Hardy create and maintain a sense of mystery and malignant, uncontrollable forces in The withered arm Thomas Hardy creates and maintains mystery and malignant, underlying forces by using symbolic descriptions of the setting, the atmosphere and the strange unguessable plot. Thomas Hardy sets the story in the fictional village of Holmstoke. Holm means home and stoke means fire. This gives two impressions, one of a nice cosy warm story, but it also gives the impression that fire is also connected with bad things like Hell and witchcraft. This makes you start to wonder what the story will be like. Thomas Hardy uses natural settings to contrast with unnatural events or behaviour. The heath is used a lot because of this. He also uses the heath because it helps create atmosphere and because it is outside he also uses the weather to reflect the characters mood. An example of this is when Rhoda and Gertrude cross the heath to see Conjuror Trendle and Rhoda does not want to and would have done anything to escape this enquiry, the weather and the atmosphere reflect her dread of what will happen. The thick clouds made the atmosphere dark and it was only early after noon and the wind howled dismally. Hardy also uses the weather to help him describe the changing of time like at the beginning of a paragraph. All the gossip was going on in winter and by the end of the paragraph its in the spring I think Hardy also uses the changing of the seasons as a sort of metaphor to symbolize the changing of the characters. An example is when Gertrude changes from a very beautiful, perfect, kind and caring girl to a scarred irritable superstitious woman. Hardy also has such large gap in time so the changes in Gertrude are more noticeable. Thomas Hardy also uses characters to help him create mystery and underlying forces especially Rhoda Brook. Rhoda is an outsider and she lives out of the village by herself with her son. Shes a little weird because she never mixes with people. People dont really mix with her because of her sleeping with Lodge and having a baby. People think she is a witch. I think this is because people associate her with Trendle. When Gertrude needed to find Trendle the villagers told her to ask Rhoda and she realized that they thought a sorceress would know the whereabouts of the exorcist. But the mystery really begins when she has her vision and next day Gertrude shows her the mark from the vision which is on her arm. The vision is an important part of the story as it is the start of everything and caused everything. Rhoda can not control what is happening to so it helps maintain the uncontrollable forces which are all through this book. Thomas Hardy uses Conjuror Trendle a lot to help create mystery and uncontrollable forces. Just the fact that conjuror Trendle lives on the heath starts to make the reader feel a sense of mystery because the heath represents the weirdness or the story. Trendle also helps create mystery by doing magic in secret and not openly He did not profess his remedial practises openly and it also helps that he was in disguise. He was disguised as a dealer in furze , turf sharp sand and other local products. He had to be disguised because people in that time were very superstitious. I think Thomas Hardy uses Gertrude to help create a sense of uncontrollable forces, this is because things are happening to her mentally and physically which she has no control over. Also because the things that are happening to her are unexplainable, it helps create and maintain malignant uncontrollable forces. Hardy illustrates this physically when her incredible beauty is which is described as the light under a heap of rose petals becomes ruined and scarred by her withered arm; and mentally when she turns from a very nice person to an irritable, superstitious woman Farmer Lodge is not in the story much but none the less is a very important character, because he is the main reason the whole story happens. He is the center of the love triangle of him Rhoda and Gertrude which is why everything happens. As we dont see him much in the story this makes him more important as it helps add to the mystery. Hardy uses imagery to help the reader mentally see whats happening and also to symbolise things. An example of this at the beginning of the booking the lorn milkmaid Hardy paint us the picture of a lot of milkmaids all sitting together gossiping. This gives the impression that the village is quite a close knit place and that one Rhoda Brooke is all by herself on the side not joining in this gossiping. This gives the impression that she is a sort of outsider which no one wants to be friends with which adds to the mystery. A very important image in the story is the withered arm. It creates mystery because the reader will wonder how it happened and malignant uncontrollable forces because the reader will wonder if Rhoda really is a witch. The main themes of the story are witch craft and passion. The passion is in the love triangle between Farmer Lodge, Gertrude and Rhoda. The witch craft is in the vision Rhoda sees and the physical and mental change in Gertrude. Passion and witch craft are the uncontrollable forces in the withered arm. I think one of the things Hardy is trying to say in this book is that life cant always be explained. Thomas Hardy uses many different languages effects. He uses similes and metaphors, to describe Gertrude her face as comely as a live dolls and her face like the light under a heap of rose petals. Hardy also uses extended imagery when he uses the river outside the executioners house to link him to the village, it stood close to the same stream. He also uses personification in describing the river the waters of which emitted a steady roar. Thomas Hardy shows us which characters are common and which arent by having the common ones use dialect. The only person not to use dialect is Gertrude. Another important factor in creating and maintaining a sense of mystery and malignant uncontrollable forces was the plot. The vision coming true and Rhoda beginning to doubt herself really draws the reader in to the story. I think it was a very effective ending giving no clear answers like yes, Rhoda was a witch or not or no, it was all a coincidence and leaving it up to the reader. That really helps maintain mystery In conclusion I think that by using the characters, settings and a strange plot, Thomas Hardy successfully creates and maintains mystery and malignant forces in the withered arm.

The Call of the Wild Essay -- essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  The Call of the Wild   Ã‚  Ã‚  Ã‚  Ã‚  The Call of the Wild, by Jack London, is a classic piece of American literature. The novel follows the life of a dog named Buck as his world changes and in turn forces him to become an entirely new dog. Cruel circumstances require Buck to lose his carefree attitude and somewhat peaceful outlook on life. Love then enters his life and causes him to see life through new eyes. In the end, however, he must choose between the master he loves or the wildness he belongs in.   Ã‚  Ã‚  Ã‚  Ã‚  The novel starts on Judge Miller’s property in Santa Clara Valley. Buck is the king of his domain and everyone knows it - from the lowly house dogs to the Judge’s sons. However, a gardener with a gambling problem soon ends Buck’s relaxed life. He sells Buck in order to obtain more money; Buck is sent west to be a sled dog and is cruelly mistreated along the way.   Ã‚  Ã‚  Ã‚  Ã‚  A quick learner, he adapts well to the sled dog life. His heritage also helped him become accustomed to the harsh Klondike climate. Some difficulties such as sore feet and a voracious appetite set him back at the beginning, but he speedily overcomes them. Buck goes through several masters and many thousands of miles. Along the way, he learns â€Å"The Law of Club and Fang†: never challenge a human that has a weapon, and once a fighting dog falls to the ground, roaming huskies quickly destroy it.   Ã‚  Ã‚   ...

Relationships :: essays research papers

I. IntroductionLast fall, 700,000 men gathered at our nation's Capital to focus on mending relationships. Their goals were to help men end adulterous behavior, quit abusing and neglecting the women and children in their lives, and renew their promises to their families. Knowing this, it is hard to understand why this rally would be seen as a threat rather than honorable. Imagine 700,000 men acknowledging the areas in which they've failed and wanting to take responsibility for their actions. My father was one of these men. Knowing him in the capacity that I do, anything or anyone that can make him acknowledge his imperfections is to be admired! Now why am I telling you this? Why does it matter? People perceived these men as a threat. They were neither welcomed nor respected for taking a stand in what they felt was important. This matters because Conservative Christian thinkers are forced to face this type of discriminating judgement daily.II. One article that I read pertaining to the Promise Keeper gathering was titled "Invasion of the Promise Keepers." (a) I found this rather ironic. Why would men eager to finally take responsibility be seen as "invading?" As a woman, I would rather be with a man who openly admitted that he wasn't always right and who respected and honored me, than to be with a man who did not.(b) Evidently, however, not all women want to be appreciated. Many openly condemned them for their attempts. Protestors of both genders greeted these men with the phrase "racist, sexist, homophobe, go home."III. In an issue of Time, one reporter addresses this type of religious discrimination. He states that "the fight is not so much over what people ought to believe; it is over what they can say, and where, and to whom." He then goes on to give the following examples:(a) The Pennsylvania Supreme Court threw out the sentence of a murderer who killed a 70-year-old woman with an ax because the prosecuting attorney cited Biblical law in requesting the death penalty.(b) In Decateur, IL, an elementary, public school teacher demanded that her seven-year-old students mark out the word "God" printed in their phonics book.(c) In Oak Park, IL, a private Catholic hospital was not allowed to erect a cross because it could potentially offend some the town's residents.IV. As one who has experienced this particular type of discrimination, I have often wondered why someone would form a general opinion of disgust with such a large, diverse group of people.

Computer-assisted translation Essay

A literal translation is a translation that follows closely the form of the source language. Also known as: | word-for-word translation| Literal translation, or directed translation, is the rendering of text from one language to another â€Å"word-for-word† (Latin: â€Å"verbum pro verbo†) rather than conveying the sense of the original. (This distinction is valid only when a literal translation does not accurately convey the sense, which is not invariably true.) Literal translation, or directed translation, is the rendering of text from one language to another â€Å"word-for-word† (Latin: â€Å"verbum pro verbo†) rather than conveying the sense of the original. (This distinction is valid only when a literal translation does not accurately convey the sense, which is not invariably true. ) In translation studies, â€Å"literal translation† denotes technical translation of scientific, technical, technological or legal texts. [1] In translation theory, another term for â€Å"literal translation† is â€Å"metaphrase†; and for phrasal (â€Å"sense†) translation — â€Å"paraphrase. † When considered a bad practice of conveying word by word (lexeme to lexeme, or morpheme to lexeme) translation of non-technical type literal translations has the meaning of mistranslating idioms,[2] for example, or in the context of translating an analytic language to a synthetic language, it renders even the grammar unintelligible. Term in translation studies Usage The term â€Å"literal translation† often appeared in the titles of 19th-century English translations of classical, Bible and other texts. Cribs Literal translations (â€Å"cribs,† â€Å"ponies†, or â€Å"trots†) are sometimes prepared for a writer who is translating a work written in a language he does not know. For example, Robert Pinsky is reported to have used a literal translation in preparing his translation of Dante’s Inferno (1994), as he does not know Italian. [citation needed] Similarly, Richard Pevear worked from literal translations provided by his wife, Larissa Volokhonsky, in their translations of several Russian novels. [citation needed]. Poetry to prose Literal translation can also denote a translation that represents the precise meaning of the original text but does not attempt to convey its style, beauty, or poetry. There is, however, a great deal of difference between a literal translation of a poetic work and a prose translation. A literal translation of poetry may be in prose rather than verse, but also be error free. Charles Singleton’s translation of The Divine Comedy (1975) is regarded as a prose translation. As a bad practice  Ã¢â‚¬Å"Literal† translation implies that it is probably full of errors, since the translator has made no effort to convey, for example, correct idioms or shades of meaning. Examples A literal English translation of the German word â€Å"Kindergarten† would be â€Å"children garden,† but in English the expression refers to the school year between pre-school and first grade. Literal translations in which individual components within words or compounds are translated to create new lexical items in the target language (a process also known as â€Å"loan translation†) are called calques, e.g. , â€Å"beer garden† from German â€Å"Biergarten. † Literal translation of the Italian sentence, â€Å"So che questo non va bene† (â€Å"I know that this is not good†), produces â€Å"Know(I) that this not goes(it) well,† which has English words and Italian grammar. Machine translation Early machine translations (as of 1962[3] at least) were notorious for this type of translation as they simply employed a database of words and their translations. Later attempts utilized common phrases which resulted in better grammatical structure and capture of idioms but with many words left in the original language. For translating synthetic languages, a morphosyntactic analyzer and synthesizer is required. The best systems today use a combination of the above technologies and apply algorithms to correct the â€Å"natural† sound of the translation. In the end though, professional translation firms that employ machine translation use it as a tool to create a rough translation that is then tweaked by a human, professional  translator. Pidgins Often, first-generation immigrants create something of a literal translation in how they speak their parents’ native language. This results in a mix of the two languages in something of a pidgin. Many such mixes have specific names, e. g. Spanglish or Germish. For example, American children of German immigrants are heard using â€Å"rockingstool† from the German word â€Å"Schaukelstuhl† instead of â€Å"rocking chair†. Mistranslations Literal translation of idioms is a source of numerous translators’ jokes and apocrypha. The following famous example has often been told both in the context of newbie translators and that of machine translation: When the sentence â€Å"The spirit is willing, but the flesh is weak† (Ð ´Ã'Æ'Ã'… Ð ±Ã ¾Ã ´Ã'€, Ð ¿Ã »Ã ¾Ã'‚Ã'Å' Ð ¶Ã µ Ð ½Ã µÃ ¼Ã ¾Ã'‰Ð ½Ã °, an allusion to Mark 14:38) was translated into Russian and then back to English, the result was â€Å"The vodka is good, but the meat is rotten† (Ã' Ã ¿Ã ¸Ã'€Ã'‚, Ð ºÃ ¾Ã ½Ã µÃ'‡Ð ½Ã ¾, Ð ³Ã ¾Ã'‚Ð ¾Ã ², Ð ½Ã ¾ Ð ¼Ã' Ã' Ã ¾ Ð ¿Ã'€Ð ¾Ã'‚Ã'Æ'Ã'…Ð »Ã ¾). This is generally believed to be simply an amusing story, and not a factual reference to an actual machine translation error. [4] Rating Scales for Narrative (open-ended or constructed) Questions Question: secretarial experience 76| Well QualifiedCandidate has extensive independent secretarial/clerical experience (may be more than approximately five years). Candidate has extensive experience dealing with a wide variety of complex issues relative to challenges encountered in the secretarial/clerical work environment. Candidate provides specific details with respect to the diversity of tasks/projects they were involved in, and his/her roles and responsibilities. Candidate’s response is thorough and complete and completely addresses the question. | 543| QualifiedCandidate has adequate independent secretarial/clerical experience (may be approximately three to four years). Candidate has experience dealing with a variety of complex issues relative to challenges encountered in the secretarial/clerical work environment; however, his/her experience is not as thorough as that of the well-qualified candidate. Candidate provides specific details in the same areas described for the well-qualified candidate. Candidate’s response is complete and addresses the question. | 21| Limited QualificationCandidate has limited independent secretarial/clerical experience (may be less than approximately three years). Candidate may have some experience, but that experience is limited or presented vaguely. Candidate may not provide specific details in response to the question. Candidate’s response may not be clear or complete. Candidate’s experience is limited and not at the level required for this position. | Question: social services experience. 76| Well QualifiedCandidate has extensive experience providing professional level social services (may be more than approximately four years). Candidate has experience dealing with a wide variety of issues relative to providing these services. Candidate provides specific details with respect to the services they have provided, the diversity of tasks/projects completed, and his/her role and responsibility. Candidate’s response is thorough and complete and addresses all of the above-outlined areas. | 543| QualifiedCandidate has adequate experience providing professional level social services (may be approximately three to four years). Candidate has experience dealing with a variety of issues relative to providing these services; however, his/her experience is not as thorough as that of the well-qualified candidate. Candidate provides specific details in the same areas described for the well-qualified candidate. Candidate’s response is complete and addresses all of these areas. | 21| Limited QualificationCandidate lacks adequate experience providing professional level social services (may be less than approximately three years), as required for this position. Candidate may have some experience, but that experience is limited or presented vaguely. Candidate may not provide specific details in response to the outlined areas of the question. Candidate’s response may not be clear or complete. Candidate’s experience is limited and not at the level required for this position. | Question: experience working with involuntarily committed individuals in a secured setting 76| Well QualifiedCandidate has extensive experience working with involuntarily committed individuals in a secured setting (may be approximately two years). Candidate has experience dealing with a variety of tasks in this setting, including basic cleaning and maintenance. Candidate provides specific details with respect to the duties performed, diversity of situations encountered, and his/her role in providing service. Candidate’s response is thorough and complete and addresses all of the above-outlined areas. | 543| QualifiedCandidate has adequate experience working with involuntarily committed individuals in a secured setting (may be approximately one year). Candidate has experience dealing with the most important tasks (e. g. , perimeter patrol); however, his/her experience is not as thorough as that of the well-qualified candidate. Candidate provides specific details in the same areas described for the well-qualified candidate. Candidate’s response is complete and adequately addresses the question. | 21| Limited QualificationCandidate lacks adequate experience working with involuntarily committed individuals in a secured setting (may be less than one year), as required for this position. Candidate may have some experience, but that experience is limited or presented vaguely. Candidate may not provide specific details in response to the scope of the question. Candidate’s response may not be clear or complete. Candidate’s experience is limited and not at the level required for this position. | Question: interview experience 76| Well QualifiedCandidate has extensive experience interviewing clients to gather information (may be more than approximately two years). Candidate has experience dealing with a wide variety of individuals in a range of situations and specifically identifies the communication medium (e. g. , telephone, in-person). Candidate provides specific details with respect to the duties performed, purpose of interview, diversity of situations encountered, and his/her role. Candidate’s response is thorough and complete and addresses all of the above-outlined areas. | 543| QualifiedCandidate has adequate experience interviewing clients to gather information (may be approximately one to two years). Candidate has experience dealing with a variety of issues relative to interviewing; however, his/her experience is not as thorough as that of the well-qualified candidate. Candidate provides specific details in the same areas described for the well-qualified candidate. Candidate’s response is complete and addresses all of these areas. | 21| Limited QualificationCandidate lacks  adequate experience conducting interviews with clients (may be less than approximately one year), as required for this position. Candidate may have some experience, but that experience is limited or presented vaguely. Candidate may not provide specific details in response to the scope of the question. Candidate’s response may not be clear or complete. Candidate’s experience is limited and not at the level required for this position. | Question: customer service experience 76| Well QualifiedCandidate has extensive customer service experience (may be more than approximately three years). Candidate has experience dealing with a wide variety of individuals in a range of situations (including communicating with difficult and/or hostile customers/clients). Candidate provides specific details with respect to the duties performed, purpose of customer service, diversity of situations encountered, and his/her role in providing service. Candidate’s response is thorough and complete and addresses all of the above-outlined areas. | 543| QualifiedCandidate has adequate customer service experience (may be approximately one to two years). Candidate has experience dealing with a variety of issues relative to providing customer service; however, his/her experience is not as thorough as that of the well-qualified candidate. Candidate provides specific details in the same areas described for the well-qualified candidate. Candidate’s response is complete and addresses all of these areas. | 21| Limited QualificationCandidate lacks adequate experience providing customer service (may be less than approximately one year), as required for this position. Candidate may have some experience, but that experience is limited or presented vaguely. Candidate may not provide specific details in response to the scope of the question. Candidate’s response may not be clear or complete. Candidate’s experience is limited and not at the level required for this position. | Semantic differential scale http://edutechwiki. unige. ch/en/Semantic_differential_scale#Examples Attitude scale for a web site (S. Kim MacGregor and Yiping Lou) * boring-interesting * meaningless-meaningful * important-unimportant, * informative-uninformative * disorganized-organized * easy-difficult Websites From UPA’s web maintenance and design, retrieved April 11, 2011. The XXX association whose web site looks like this is: Unfriendly__1__2__3__4__5__6__7Friendly Amateurish__1__2__3__4__5__6__7Professional Ineffective__1__2__3__4__5__6__7Effective Dull__1__2__3__4__5__6__7Interesting Outdated__1__2__3__4__5__6__7Up-to-date Serious __1__2__3__4__5__6__7 Fun Weak__1__2__3__4__5__6__7Strong This visual design is: Cluttered__1__2__3__4__5__6__7Simple Unbalanced__1__2__3__4__5__6__7Balanced Unpleasant__1__2__3__4__5__6__7Pleasant Delicate__1__2__3__4__5__6__7Bold Confusing__1__2__3__4__5__6__7Clear Self report NURSING EXPERTISE SELF-REPORT SCALE Please circle the answer that best describes you. * 1. I am an: RN Other * 2. My job is: Staff nurse Assistant Nurse Manager Other * 3. Length of time since graduating as an RN: Under 6 months 6 * months to 3 years More than 3 years * 4. Length of time working on your unit:: Under 6 months 6 months to * 3 years More than 3 years * 5. Previous experience in nursing prior to graduating as an RN: Under * 6 months 6 months to 3 years More than 3 years The following is a list of statements about nursing care. Please circle the number that best represents your agreement with the statement. 1. Strongly Agree 2. Agree 3. Unsure 4. Disagree 5. Strongly Disagree * 1. I often know ahead of time that my patient will take a turn for the worse. 1 * 2. I frequently draw on past experiences when making patient care decisions. 2 * 3. Quality nursing care results from strictly adhering to policy and procedure. 5 * 4. When I do patient care, only a few pieces of information stand out as critically important. 2 * 5. I am consciously aware of the process of decision making in patient care. 1 * 6. Emotional attachments get in the way of good nursing care. 5 * 7. When something goes wrong with my patient, I seem to know automatically what to do. 2 * 8. Sometimes I find it difficult to identify objective reasons for certain patient care decisions. 2 * 9. The best way to give good nursing care is to get close to the patient. 2 * 10. I find it time consuming to set priorities in patient care. 5 * 11. I make my best decisions about patient care when I remain objective. 4 * 12. In an emergency, things happen so quickly that I don’t know what to do. 5 * 13. I base my patient care decisions more often on the rules that I learned in nursing school than on my experience in patient care. 5 * 14. It seems obvious to me what things need to be done first for my patients. 2 * 15. I use facts such as lab values and vital signs as my main source of information for making patient care decisions. 5 * 16. I usually require a lot of information about a patient care situation before I am comfortable with making a decision. 4 * 17. I do my best nursing care when I become truly involved with the patient. 1 * 18. I am comfortable with altering standard patient care procedures when I see the need. 3 * 19. Sudden patient care emergencies usually come as a complete surprise to me. 5 * 20. Most often I find myself relying on gut feelings when it comes to patient care. 5 Source: Reprinted with permission from G. Garland, Self-Report of Competence, Journal of Nursing Staff Development, Vol. 12, No. 4, p. 197, 1996, Lippincott-Raven. http://www. research-paper-example. com/nursing-self-report-scale. html http://upload. wikimedia. org/wikipedia/commons/c/cc/Example_Likert_Scale. svg Administering the thurstone scale Here is the final form. The respondents check only the statements with which they agree. The average ratings by the judges are shown in parentheses. These would not be included on the actual form given to respondents. Note that the more positive statements have a higher weight. This is a scale to measure your attitude toward marijuana. It does not deal with any other drug, so please consider that the items pertain to marijuana exclusively. We want to know how students feel about this topic. In order to get honest answers, the questionnaires are to be filled out anonymously. Do not sign your name. Please check all those statements with which you agree. | ___| 1. | I don’t approve of something that puts you out of a normal state of mind. (3.0) | ___| 2. | It has its place. (7. 1) | ___| 3. | It corrupts the individual (2. 2) | ___| 4. | Marijuana does some people a lot of good. (7. 9). | ___| 5. | Having never tried marijuana, I can’t say what effects it would have. (6. 0) | ___| 6. | If marijuana is taken safely, its effect can be quite enjoyable. (8. 9) | ___| 7. | I think it is horrible and corrupting. (1. 6) | ___| 8. | It is usually the drug people start on before addiction. (4. 9) | ___| 9. | It is perfectly healthy and should be legalized. (10. 0) | ___| 10. | Its use by an individual could be the beginning of a sad situation. (4. 1) | http://psychology. ucdavis. edu/sommerb/sommerdemo/scaling/enrich/thurstone. html Iba ang Pinoy ni Princess O. Canlas Ang Pilipinas ay binubuo ng iba’t ibang lalawigan, at bawat lalawigan ay may kanya-kanyang bernakular. Ngunit iba-iba man ang salita, iba-iba mang lugar ang kinalakihan, iisa lang ang ugat na pinagmulan. Tayo ay Pilipino. Mahirap malaman kung ang isang tao ay Pilipino nga o hindi sa kasalukuyang panahon. Sapagkat ang iba sa atin ay mas nananalantay ang dugong banyaga. At kung minsan pa’y mahirap ding alamin sa kanilang gamit na wika. May maitim at mayroon namang maputi. May matangos ang ilong at mayroon namang sarat. May matangkad at mayroon din namang pandak. Ngunit isang katangian ang nagbubuklod sa mga Pilipino upang sila’y makilala mo at masabing: â€Å"IBA ANG PINOY! † Ang pagkakawanggawa ay may taglay na iba’t ibang katangian. Sapagkat ang taong mapagkawanggawa ay masasabi ring matulungin sa kapwa, magalang, mabait, mapagbigay, mapagpaumanhin, mapagtimpi, o mapang-unawa. At ang pagkakawanggawang ito ang makikita sa mga Pilipino. Isang katangiang higit sa kayamanan. Mapapansin hanggang sa kasalukuyan na ang Pinoy ay may kusang loob na pagtulong sa mga taong nasa kanyang paligid, kilala man niya ang mga ito o hindi. Sa lansangan, ang mga bata ay tinutulungang makatawid nang matiwasay. Ang matatanda ay inaalalayan sa kanilang paglalakad. Ang maraming dala-dalahan ay tinutulungan sa pagbibitbit. Ang mga hindi sinasadyang mahulog na bagay ay pinupulot upang iabot. Ang mga upuan sa pampublikong sasakyan ay ipinagkakaloob ng mga kalalakihan sa matatanda o sa kababaihan. Pagbibigay ng pagkain sa mga nagugutom. Pagbabahagi sa mga nangangailangan. Pagtanggap sa mga bisita nang may sigla, paghahain ng pagkain kahit kung minsan ay wala ng matira para sa kanila. At minsan nama’y pag-ako sa mga gawaing naiwan ng iba. At ang lahat ng mga ito ay ginawa ng kusang-loob at hindi napilitan lamang. Iyan ang Pinoy. Likas sa mga Pilipino ang pagkakawanggawa. At ang kalikasang ito ay dapat ingatan at pagyamanin pa. Nababatid ba natin na ang katangiang ito ay nakapagkukubli ng mga pagkukulang na ating nagawa sa mata ng Diyos? Sa iyong paggawa ng kabutihan, maaring may mga pagkakataon na ika’y hindi napasalamatan o nginitian man lamang ng iyong tinulungan. At ang iyong ginawa akala mo’y walang saysay o walang kabuluhan. Ngunit may Isang higit sa lahat ay nakakaalam. At Siya ang tanging makapagsusukli sa iyong kabutihan. Ang paggawa ng kabutihan sa kapwa ay may katumbas na gantimpala sa Panginoon. Ngunit hindi man natin makamit ang biyayang iyon dito sa lupa, makasisiguro tayong sa langit ay ipagkakaloob ng Diyos ang gantimpala. Tayo’y mga Pilipino, at nananalantay rin sa ating ugat ang dugong Kristiyano. Ang pagkakawanggawa ay patuloy nating ihandog o ibahagi sa ating kapwa. At hayaang ang ibang bansa ang magsabing, Pinoy ay dakila!

Science Explains Why Rotten Eggs Float

Science Explains Why Rotten Eggs Float One of the ways to tell whether an egg is rotten or still good is to use the flotation test. To perform the test, you place the egg in a glass of water. Fresh eggs typically rest at the bottom of the glass. An egg that sinks but rests with the large end facing up may be a bit older but is still fine for cooking and eating. If the egg floats, its old and may be rotten. You can test this for yourself, although to be scientific about it, youll need to crack open the egg to observe its appearance and smell it to be certain eggs are good or bad (trust me, youll know the bad ones). Youll find the test is fairly accurate. So, you may be wondering why the bad eggs float. Why Bad Eggs Float Fresh eggs sink because the egg yolk, egg white, and gases have enough mass that the density of the egg is greater than the density of water. Density is the mass per unit of volume. Basically, a fresh egg is heavier than water. When an egg starts to go off decomposition occurs. Decomposition gives off gases. As more of the egg decomposes, more of its mass is converted to gases. A gas bubble forms inside the egg so an older egg floats on its end. However, eggs are porous, so some of the gas escapes through the eggshell and is lost to the atmosphere. Although gases are light, they do have mass and affect the density of the egg. When enough gas is lost, the density of the egg is less than that of water and the egg floats. Its a common misconception that rotten eggs float because they contain more gas. If the inside of an egg rotted and the gas couldnt escape, the mass of the egg would be unchanged. Its density would also be unchanged because the volume of an egg is constant (i.e., eggs dont expand like balloons). Changing matter from the liquid state to the gas state doesnt change the amount of mass! The gas has to leave the egg for it to float. Gas With a Rotten Egg Smell If you crack open a rotten egg, the yolk may be discolored and the white may be cloudy rather than clear. More likely, you wont notice the color because the overwhelming stink of the egg will send you off to go throw up. The smell is from the gas hydrogen sulfide (H2S). The gas is heavier than air, flammable, and toxic.   Brown Eggs vs. White Eggs You may be wondering whether it matters if you try the flotation test on brown eggs versus white eggs. The results will be the same. There is no difference between brown eggs and white eggs except for their color, assuming the chickens were fed the same grain. Chickens with white feathers and white earlobes lay white eggs. Brown or red chickens that have red earlobes lay brown eggs. The egg color is controlled by a gene for eggshell color that does not affect the thickness of the shell. There are also chicken eggs with blue shells and some with speckled shells. Again, these are simple color differences that do not affect the structure of the eggshell or the result of the flotation test. Egg Expiration Dates The expiration date on a carton of eggs isnt always a good indicator of whether or not the eggs are still fresh. In the United States, the USDA requires egg expiration dates be no longer than 30 days from the packing date. Unrefrigerated eggs may not make it the full month before going off. Refrigerated eggs are more likely to dry up than go bad. The pores of egg shells are small enough bacteria arent going to enter the egg and start reproducing. However, some eggs naturally contain a small number of bacteria, which are more likely to grow in a warmer, more favorable environment. Its worth noting the rotten egg smell isnt just from bacterial decomposition of an egg. Over time, the egg yolk and egg white become more alkaline. This occurs because eggs contain carbon dioxide in the form of carbonic acid. Carbonic acid slowly escapes the egg as carbon dioxide gas that passes through the pores in the shell. As the egg becomes more alkaline, the sulfur in the egg becomes better able to react with hydrogen to form hydrogen sulfide gas. This chemical process occurs more rapidly at room temperature than at cooler temperatures. Another Way to Tell If an Egg Is Bad If you dont have a glass of water handy, you can test an egg for freshness by holding it up to your ear, shaking it, and listening. A fresh egg shouldnt make much sound. An older egg will slosh around more because the gas pocket is larger (giving it room to move) and the egg has lost some cohesion.

Coco Chanel Essay Example

Coco Chanel Essay Example Coco Chanel Essay Coco Chanel Essay In 1939, at the beginning of World War II, Chanel closed her shops, maintaining her apartment situated above the couture house at 31 rue Cambon. She claimed that it was not a time for fashion. [19] Three thousand female employees lost their jobs. [37] The advent of war had given Chanel the opportunity to retaliate against those workers, who lobbying for fair wages and work hours, had closed down her business operation during the general labor strike in France in 1936. In closing her couture house, Chanel made a definitive statement of her political views. Her visceral loathing of Jews inculcated by her convent years, and sharpened by her aristocratic associations over time, had solidified her right-wing beliefs. She shared with most of her circle the conviction that Jews and liberal politicians were a Bolshevik threat to Europe. [38] During the German occupation Chanel resided at the Hotel Ritz, which was also noteworthy for being the preferred place of residence for upper echelon German military staff. Her romantic liaison with Hans Gunther von Dincklage, a German officer who had been an operative in military intelligence since 1920, [39]facilitated her arrangement to reside at the Ritz. [40] World War II, specifically the Nazi seizure of all Jewish-owned property and business enterprises, provided Chanel with the opportunity to gain the full monetary fortune generated by Parfums Chanel and its most profitable product, Chanel No. 5. The directors of Parfums Chanel, the Wertheimers, were Jewish, and Chanel used her position as an â€Å"Aryan† to petition German officials to legalize her claim to sole ownership. On May 5, 1941, she wrote to the government administrator charged with ruling on the disposition of Jewish financial assets. Her grounds for proprietary ownership were based on the claim that â€Å"Parfums Chanel â€Å"is still the property of Jews†Ã¢â‚¬ ¦and had been legally â€Å"abandoned† by the owners. [41] â€Å"I have,† she wrote, â€Å"an indisputable right of priority†¦the profits that I have received from my creations since the foundation of this business†¦are disproportionate†¦[and] you can help to repair in part the prejudices I have suffered in the course of these seventeen years. [42] Chanel was not aware that the Wertheimers, anticipating the forthcoming Nazi mandates against Jews had, in May 1940, legally turned control of â€Å"Parfums Chanel† over to a Christian, French businessman and industrialist, Felix Amiot. [41] Ultimately, the Wertheimers and Chanel came to a mutual accommodation, re-negotiating the original 1924 c ontract. On May 17, 1947, Chanel received wartime profits from the sale of Chanel No. 5, an amount equivalent to some nine million dollars in twenty-first century valuation. Further, her future share would be two percent of all Chanel No. sales worldwide. The financial benefit to her would be enormous. Her earnings would be in the vicinity of twenty-five million dollars a year, making her at the time one of the richest women in the world. [43][44] [edit]Activity as Nazi Agent Archival documents verify that Chanel herself was a Nazi spy, committing herself to the German cause as early as 1941, when she became a paid agent of General Walter Schellenberg, chief of SS intelligence. [45] Her clandestine identity was Abwehr Agent 7124, code name â€Å"Westminster. [46] At war’s end, Schellenberg was tried by the Nuremberg Military Tribunal, and sentenced to six years imprisonment for war crimes. He was released in 1951 due to incurable liver disease, and took refuge in Italy. Chan el paid for Schellenberg’s medical care and living expenses for himself, wife and family until his death in 1952. [47] [edit]â€Å"Operation Modellhut† In 1943, Chanel traveled to Berlin with Dinklage to meet with SS Reichsfurer, Heinrich Himmler to formulate strategy. [48] In late 1943 or early 1944, Chanel and her SS master, Schellenberg, devised a plan to press England to end hostilities with Germany. When interrogated by British intelligence at war’s end, Schellenberg maintained that Chanel was â€Å"a person who knew Churchill sufficiently to undertake political negotiations with him. † [49] For this mission, named â€Å"Operation Modellhut,† (â€Å"Model Hat† in English) they recruited Vera Lombardi. Unaware of the machinations of Schellenberg and her old friend Chanel, Vera played the part of their unwitting dupe, led to believe that the forthcoming journey to Madrid would be a business trip exploring the possibilities of establishing the Chanel couture in Madrid. Vera’s role was to act as intermediary, delivering a letter penned by Chanel to Winston Churchill, and forwarded to him via the British embassy in Madrid. [50] Schellenberg’s SS laison officer, Captain Walter Kutcschmann, acted as bagman, â€Å"told to deliver a large sum of money to Chanel in Madrid. † [51] The mission was a failure. British intelligence files reveal that all collapsed, as Vera, on arrival, proceeded to denounce Chanel and others as Nazi spies. [52] [edit]Protection from prosecution In September 1944, Chanel was called in to be interrogated by the Free French Purge Committee, the epuration. The committee, which had no documented evidence of her collaboration activity, was obliged to release her. According to Chanel’s grand-niece, Gabrielle Palasse Labrunie, when Chanel returned home she said, â€Å"Churchill had me freed. † [53] The extent of Winston Churchill’s intervention can only be speculated upon. However, Chanel’s escape from prosecution certainly speaks of layers of conspiracy, protection at the highest levels. It was feared that if Chanel were ever made to testify at trial, the pro-Nazi sympathies and activities of top-level British officials, members of the society elite and those of the royal family itself would be exposed. It is believed that Churchill instructed Duff Cooper, British ambassador to the French provisional government, to â€Å"protect Chanel. † [54] Finally induced to appear in Paris before investigators in 1949, Chanel left her retreat in Switzerland to confront testimony given against her at the war crime trial of Baron Louis de Vaufreland, a French traitor and highly placed German intelligence agent. Chanel denied all accusations brought against her. She offered the presiding judge, Leclercq, a character reference: â€Å"I could arrange for a declaration to come from Mr. Duff Cooper. † [55] Chanel’s friend and biographer Marcel Haedrich provided a telling estimation of her wartime interaction with the Nazi regime: â€Å"If one took seriously the few disclosures that Mademoiselle Chanel allowed herself to make about those black years of the occupation, one’s teeth would be set on edge. †[56]